Author/Authors :
Lee، نويسنده , , Jaemoon and Hoang، نويسنده , , Thoa and Lewis، نويسنده , , Stephanie and Weissman، نويسنده , , Steven A and Askin، نويسنده , , David and Volante، نويسنده , , R.P and Reider، نويسنده , , P.J، نويسنده ,
Abstract :
A catalytic highly enantioselective (99% ee) preparation of N-tert-butyloxycarbonyl-(2S,3S)-3-hydroxy-2-phenyl-piperidine and N-tert-butyloxycarbonyl-(2S)-2-phenyl-piperidin-3-one was developed using an intramolecular epoxide opening followed by ring expansion. The cis-epoxide starting material was available in high ee via Jacobsen epoxidation.
