Title of article :
Orostanal, a novel abeo-sterol inducing apoptosis in leukemia cell from a marine sponge, Stelletta hiwasaensis
Author/Authors :
Miyamoto، نويسنده , , Tomofumi and Kodama، نويسنده , , Kota and Aramaki، نويسنده , , Yuko and Higuchi، نويسنده , , Ryuichi and Van Soest، نويسنده , , Rob W.M. van Soest، نويسنده ,
Abstract :
A sterol derivative, orostanal, was obtained from a marine sponge of Stelletta hiwasaensis. Spectroscopic analysis and synthetic study revealed its structure as a novel 5(6→7)abeo-sterol. Orostanal and its synthetic analog induce apoptosis in human acute promyelotic leukemia cell.
