Title of article
An efficient synthesis of a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 via asymmetric dianionic cyanomethylation of N-Boc-l-(+)-glutamic acid dimethyl ester
Author/Authors
Tian، نويسنده , , Qingping and Nayyar، نويسنده , , Naresh K and Babu، نويسنده , , Srinivasan and Chen، نويسنده , , Lijian and Tao، نويسنده , , Junhua and Lee، نويسنده , , Steven and Tibbetts، نويسنده , , Anthony P. Moran، نويسنده , , Terence and Liou، نويسنده , , Jason and Guo، نويسنده , , Ming and Kennedy، نويسنده , , Timothy P، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
6807
To page
6809
Abstract
An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc-l-(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogram quantities with an overall yield of 30%.
Keywords
asymmetric synthesis , Alkylation , lactams
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1647273
Link To Document