Title of article :
A highly efficient synthesis of 2-[3-aminopropyl]-5,6,7,8-tetrahydronaphthyridine via a double Suzuki reaction and a Chichibabin cyclization
Author/Authors :
Palucki، نويسنده , , Michael and Hughes، نويسنده , , David A and Yasuda، نويسنده , , Nobuyoshi and Yang، نويسنده , , Chunhua and Reider، نويسنده , , Paul J، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
Synthesis of 2-[3-aminopropyl]-5,6,7,8-tetrahydronaphthyridine was accomplished via a one-pot double Suzuki reaction followed by deprotection and a highly regioselective intramolecular Chichibabin cyclization. A variety of reactions conditions were screened for the Chichibabin cyclization including choice of base, solvent and reaction temperature.
Keywords :
cyclization , Suzuki–Miyaura reactions , naphthyridines , amination
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
