Author/Authors :
Jِnsson، نويسنده , , Daniel and Erlandsson، نويسنده , , Mikael and Undén، نويسنده , , Anders، نويسنده ,
Abstract :
A solid-phase approach for the synthesis of oxygen-bridged tetrahydropyridones has been developed. A diamine is attached to Trt-Cl resin and condensed with different aliphatic or aromatic ketones and coumarin-3-carboxylic acid for 20 h and cleaved with 5% TFA in DCM, resulting in tri or tetracyclic products in moderate to high yield.
