Title of article
Lipase-catalyzed enantioselective desymmetrization of prochiral 3,3-bis(hydroxymethyl)oxindoles
Author/Authors
Akai، نويسنده , , Shuji and Tsujino، نويسنده , , Toshiaki and Naka، نويسنده , , Tadaatsu and Tanimoto، نويسنده , , Kouichi and Kita، نويسنده , , Yasuyuki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
7315
To page
7317
Abstract
Oxindoles 3b–d (91–98% ee) having a chiral quaternary carbon center at the C-3 position were prepared from readily available oxindoles 5a–c in 50–64% overall yields, in which an enantioselective desymmetrization of prochiral 1,3-diols 2b–d using a Candida rugosa lipase (Meito OF) and 1-ethoxyvinyl 2-furoate 1 was employed as the key step.
Keywords
lipase-catalyzed desymmetrization , quaternary carbon center , oxindole , prochiral 1 , 3-diol
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1647629
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