Title of article
Synthesis of (3R*,4R*)-4-acetylamino-3-(pent-3-oxy)cyclohex-1-ene-1-carboxylic acid and its (3S*,4R*)-isomer and their inhibitory action against influenza virus sialidases
Author/Authors
Kerrigan، نويسنده , , Sean A and Pritchard، نويسنده , , Robin A. J. Smith، نويسنده , , Paul W and Stoodley، نويسنده , , Richard J، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
7687
To page
7690
Abstract
(3R*,4R*)-4-Acetylamino-3-(pent-3-oxy)cyclohex-1-ene-1-carboxylic acid and its (3S*,4R*)-isomer are synthesised in five steps from the Diels–Alder cycloadduct of (E)-1-acetoxy-3-methylbuta-1,3-diene and nitroethene; the former acid is a moderately potent inhibitor of influenza A sialidase.
Keywords
antivirals , oxidation (allylic) , Nitro compounds , Diels–Alder reactions
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1647919
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