Title of article
Oxidative cyclization of 1,4-dienes to yield 2,3,5-trisubstituted tetrahydrofuran-diols
Author/Authors
Travis، نويسنده , , Benjamin and Borhan، نويسنده , , Babak، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
7741
To page
7745
Abstract
KMnO4 and OsO4 catalyze the oxidative cyclization of 1,4-dienes to provide 2,3,5-trisubstituted tetrahydrofuran-diols in 30% yield. This reaction proceeds stereoselectively via a proposed [3+2] cycloaddition. Competing oxidative pathways are the major non-productive processes that reduce the yield of the reaction; however, four stereogenic centers are established in one-step.
Keywords
Oxone® , oxidative cyclization , OsO4 , 1 , 4-dienes , 2 , 3 , 5-trisubstituted THF-diols
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1647933
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