Author/Authors :
McCurdy، نويسنده , , Alison and Kawaoka، نويسنده , , Amber M and Thai، نويسنده , , Holly and Yoon، نويسنده , , Sylvia C، نويسنده ,
Abstract :
A calcium-selective photochromic chelator to study the effects of physiological [Ca2+] oscillations on proteins in vitro or in vivo has been designed. The novel 2,2′-spirobi[2H-1-benzopyran] derivative 1 has been synthesized and the ion complexation properties of 1 with Mg2+, Ca2+, and Sr2+ in aqueous buffered solution have been investigated. The chelator 1 shows modest selectivity for calcium ion (K11=6720 M−1) over magnesium ion (K11=564 M−1) by 1H NMR titration.
