iPF2α-III metabolism. First total synthesis of 2,3-dinor iPF2α-III, a primary β-oxidation metabolite

The total synthesis of a primary iPF2α-III metabolite, namely dinor iPF2α-III 8, is described. The successful synthesis was finally accomplished by generating the carboxylic acid group at the end of the synthesis so as to avoid formation of an α,β-unsaturated carboxylic acid, which is prone to undergo side reactions