Author/Authors :
Dobler، نويسنده , , Markus R and Bruce، نويسنده , , Ian and Cederbaum، نويسنده , , Fredrik and Cooke، نويسنده , , Nigel G and Diorazio، نويسنده , , Louis J and Hall، نويسنده , , Roger G and Irving، نويسنده , , Ed، نويسنده ,
Abstract :
The insecticidal activity found for rocaglamide and its congeners, prompted us to establish a short and efficient synthesis of the natural product and some synthetic ‘halo-aryl’ analogues. Pd-catalysed cross-coupling reactions of the bromo analogue were then explored in order to gain a suitable access to a broad range of unnatural analogues. The key step of our approach is a keto-aldehyde acyloin ring-closure followed by a Stiles carboxylation.
