Author/Authors :
Kamenecka، نويسنده , , Theodore M and Park، نويسنده , , You-Jung and Lin، نويسنده , , Linus S and Lanza Jr.، نويسنده , , Thomas and Hagmann، نويسنده , , William K، نويسنده ,
Abstract :
Enantioselective synthesis of 3-substituted prolines was achieved starting from commercially available 3-hydroxy-(S)-2-proline. Palladium-mediated couplings were used to introduce a variety of groups at C3 using the corresponding enol triflate derived from N-trityl 3-oxo-(S)-2-proline methyl ester. Cleavage of the trityl residue and hydrogenation provided final products with good to modest diastereoselectivity.
