Author/Authors :
LeBlond، نويسنده , , Carl R and Rossen، نويسنده , , Kai and Gortsema، نويسنده , , Frank P and Zavialov، نويسنده , , Ilia A and Cianciosi، نويسنده , , Steven J and Andrews، نويسنده , , Arthur T and Sun، نويسنده , , Yongkui، نويسنده ,
Abstract :
The evasive hypoiodous acid is generated in situ from NaOCl and NaI and used efficiently for clean iodohydroxylation of 1, producing the Crixivan® intermediate 2 in high yield with highly efficient 1,3-asymmetric induction. This pH-tunable process allows HOI generation at a pH optimal for supressing byproduct formation in pH-sensitive iodohydroxylation reactions.
