Title of article
Formal synthesis of (−)-N-acetylneuraminic acid (Neu5Ac) via desymmetrization by ring-closing metathesis
Author/Authors
Voight، نويسنده , , Eric A and Rein، نويسنده , , Christian and Burke، نويسنده , , Steven D، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
8747
To page
8749
Abstract
A formal total synthesis of (−)-N-acetylneuraminic acid (Neu5Ac), the most naturally abundant sialic acid, has been accomplished using a rigid 6,8-dioxabicyclo[3.2.1]octane template for stereoselective introduction of all oxygen and nitrogen functionality. The template was obtained via a novel ketalization/ring-closing metathesis bond construction strategy, taking advantage of an advanced intermediate in our KDN synthesis to complete the efficient assembly of Neu5Ac.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1648556
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