Title of article
A practical asymmetric synthesis of (R)-fluoxetine and its major metabolite (R)-norfluoxetine
Author/Authors
Hilborn، نويسنده , , James C. and Lu، نويسنده , , Zhi-Hui and Jurgens، نويسنده , , Alex R and Fang، نويسنده , , Q.Kevin and Byers، نويسنده , , Paul and Wald، نويسنده , , Stephen A and Senanayake، نويسنده , , Chris H، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
8919
To page
8921
Abstract
A convenient and chromatography-free synthesis for the enantiomers of fluoxetine and norfluoxetine is described. The synthesis relied on the use of the CBS reduction, and Hofman rearrangement to establish the key common intermediate 5, and enrichment of optical purity of the final product by crystallization as the tartrate salt.
Keywords
asymmetric synthesis , Fluoxetine , Norfluoxetine
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1648690
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