Author/Authors :
Telser، نويسنده , , Joachim and Beumer، نويسنده , , Raphael and Bell، نويسنده , , Andrew A and Ceccarelli، نويسنده , , Simona M and Monti، نويسنده , , Diego and Gennari، نويسنده , , Cesare، نويسنده ,
Abstract :
A strategy featuring ring-closing metathesis as key reaction is applied to the synthesis of the sarcodictyin analogue 15. The precursor diene is accessed via a brief and efficient protocol, employing multiple stereoselective allylations. Simplified analogue 15 retains microtubule stabilising properties.
Keywords :
stereocontrol , Antitumour compounds , metathesis , allylation
