Synthesis of (±) cis-substituted cyclohexenyl and cyclohexanyl nucleosides via a double Mitsunobu-type reaction

This letter describes the synthesis of (±) cis-substituted cyclohexenyl and cyclohexanyl nucleosides. The synthesis of cis isomers was successfully achieved by the use of two consecutive Mitsunobu reactions involving an inversion of configuration and a sugar–base condensation.