Author/Authors :
Sivaramakrishnan، نويسنده , , A. and Nadolski، نويسنده , , Geoffry T. and McAlexander، نويسنده , , Ian A. and Davidson، نويسنده , , Bradley S.، نويسنده ,
Abstract :
The C15–C28 fragment of the paclitaxel-like antimicrotubule agent laulimalide has been synthesized in 12 linear steps from known epoxide 5, with an overall yield of 16%. The methyldihydropyran ring of the side chain was efficiently prepared using ring-closing olefin metathesis chemistry. The 19,20-diol stereochemistry originates in starting material 7 and the side chain was appended using a Kocienski-modified Julia coupling.
