Title of article
The first direct synthesis of α-mangostin, a potent inhibitor of the acidic sphingomyelinase
Author/Authors
Iikubo، نويسنده , , Kazuhiko and Ishikawa، نويسنده , , Yuichi and Ando، نويسنده , , Noritaka and Umezawa، نويسنده , , Kazuo and Nishiyama، نويسنده , , Shigeru، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
291
To page
293
Abstract
A total synthesis of α-mangostin 1a has been achieved. The key cyclization reaction to construct the xanthone framework was undertaken by employing the PPh3–CCl4 conditions. The inhibitory activities of 1a and the benzophenone intermediate 16 against the acidic sphingomyelinase were discussed.
Keywords
apoptosis , ?-mangostin , acidic sphingomyelinase , Garcinia mangostana L.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1649197
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