Title of article :
The first direct synthesis of α-mangostin, a potent inhibitor of the acidic sphingomyelinase
Author/Authors :
Iikubo، نويسنده , , Kazuhiko and Ishikawa، نويسنده , , Yuichi and Ando، نويسنده , , Noritaka and Umezawa، نويسنده , , Kazuo and Nishiyama، نويسنده , , Shigeru، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Pages :
3
From page :
291
To page :
293
Abstract :
A total synthesis of α-mangostin 1a has been achieved. The key cyclization reaction to construct the xanthone framework was undertaken by employing the PPh3–CCl4 conditions. The inhibitory activities of 1a and the benzophenone intermediate 16 against the acidic sphingomyelinase were discussed.
Keywords :
apoptosis , ?-mangostin , acidic sphingomyelinase , Garcinia mangostana L.
Journal title :
Tetrahedron Letters
Serial Year :
2002
Journal title :
Tetrahedron Letters
Record number :
1649197
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1649197
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