Author/Authors :
Fall، نويسنده , , Yagamare and Gonzلlez، نويسنده , , Victoria and Vidal، نويسنده , , Beatriz and Mouriٌo، نويسنده , , Antonio، نويسنده ,
Abstract :
The stereoselective synthesis of 22-oxacalcitriol (OCT) has been achieved. The triene system was introduced using the Lythgoe–Hoffmann La Roche convergent Wittig–Horner approach to couple ketoester 7 with A ring phosphine oxide 8. The value of the resulting ester 6 for synthesis of C25-modified OCT analogues is exemplified by the synthesis of 5.
