Facile preparative HPLC enantioseparation of racemic drugs using chiral stationary phases based on mono-6A-azido-6A-deoxy-perphenylcarbamoylated β-cyclodextrin immobilized on silica gel

Immobilized chiral stationary phases (CSP)s from mono-6A-azido-6A-deoxy-perphenylcarbamoylated β-cyclodextrin were prepared using an extended application of the Staudinger reaction. Their application in preparative enantioseparations of racemic mixtures was demonstrated using atropine, bendroflumethiazide and four β-adrenergic blocking agents under reversed phase conditions.