Author/Authors :
Alexandre، نويسنده , , François-René and Pantaleone، نويسنده , , David P. and Taylor، نويسنده , , Paul P. and Fotheringham، نويسنده , , Ian G. and Ager، نويسنده , , David J. and Turner، نويسنده , , Nicholas J.، نويسنده ,
Abstract :
The deracemisation of dl-α-amino acids using l-amino acid oxidase from Proteus myxofaciens and amine-boranes as chemical reducing agents has been investigated. Amine-boranes were found to be of particular interest in terms of reactivity and chemoselectivity compared to sodium borohydride and cyanoborohydride. Starting from the racemate, a range of d-amino acids were obtained in yields of up to 90% and e.e. >99%.
Keywords :
d-amino acid , l-amino acid oxidase , amine–borane , deracemisation
