Title of article
The intramolecular nucleophilic 1,5-O-heterocyclization of (η4-dienyl)-tricarbonyliron diols: conformationally locked phosphocholines
Author/Authors
Braun، نويسنده , , Alain and Lellouche، نويسنده , , Jean-Paul، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
727
To page
730
Abstract
The 1,5-nucleophilic intramolecular O-heterocyclization of ψ-exo-/ψ-endo-(η4-dienyl)tricarbonyliron diols occurs under acid catalysis with a 1,2-migration of the complexation site. This cyclization proved to be stereoselective and provided a synthetically useful entry to novel conformationally locked alkylphosphocholines as potential anticancer agents.
Keywords
anticancer alkylphospholipids , (?5-dienyl)tricarbonyliron(+1) cations , intramolecular O-heterocyclization , 1 , 5-nucleophilic substitution
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1649503
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