Title of article :
The intramolecular nucleophilic 1,5-O-heterocyclization of (η4-dienyl)-tricarbonyliron diols: conformationally locked phosphocholines
Author/Authors :
Braun، نويسنده , , Alain and Lellouche، نويسنده , , Jean-Paul، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
The 1,5-nucleophilic intramolecular O-heterocyclization of ψ-exo-/ψ-endo-(η4-dienyl)tricarbonyliron diols occurs under acid catalysis with a 1,2-migration of the complexation site. This cyclization proved to be stereoselective and provided a synthetically useful entry to novel conformationally locked alkylphosphocholines as potential anticancer agents.
Keywords :
anticancer alkylphospholipids , (?5-dienyl)tricarbonyliron(+1) cations , intramolecular O-heterocyclization , 1 , 5-nucleophilic substitution
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
