Title of article
Directed lithiation of unprotected quinolinecarboxylic acids
Author/Authors
Rebstock، نويسنده , , Anne-Sophie and Mongin، نويسنده , , Florence and Trécourt، نويسنده , , Francois and Quéguiner، نويسنده , , Guy، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
767
To page
769
Abstract
The lithium salts of quinoline-2-carboxylic acid and 4-methoxyquinoline-2-carboxylic acid undergo deprotonation at C3 when treated with LTMP in THF at −25 and 0°C, respectively. The lithium salts of quinoline-3- and -4-carboxylic acids are more prone to nucleophilic addition; nevertheless, they are deprotonated at C4 and C3, respectively, when treated with LTMP in THF at −50°C.
Keywords
Quinolines , lithiation , carboxylic acids , neighbouring group effects
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1649539
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