Author/Authors :
Masayuki Okue، نويسنده , , Masayuki and Kobayashi، نويسنده , , Hiroyuki and Shin-ya، نويسنده , , Kazuo and Furihata، نويسنده , , Kazuo and Hayakawa، نويسنده , , Yoichi and Seto، نويسنده , , Haruo and Watanabe، نويسنده , , Hidenori and Kitahara، نويسنده , , Takeshi، نويسنده ,
Abstract :
A stereoselective total synthesis of the proposed structure of kaitocephalin (1) was accomplished starting from l-proline and d- and l-serines. However, its 1H NMR spectral data and retention time on HPLC were not identical with those of authentic natural kaitocephalin. The revised stereochemistry of natural kaitocephalin, (2R)-isomer (16), was inferred from further experiments employing diastereomers and model compounds.
Keywords :
kaitocephalin , total synthesis , NMDA antagonist , AMPA/KA antagonist
