High-pressure-promoted condensation of isothiocyanates with aminopyridines: efficient synthesis of pyridine–thiourea conjugates as building blocks for hydrogen-bonding receptors

New N-pyridinothiourea derivatives have been prepared by the high-pressure-promoted condensation of isothiocyanates with aminopyridines under uncatalyzed conditions. Complexation of the prototype 3c with diphenyl hydrogen phosphate was investigated by 1H NMR, and the results suggest that it may be useful as a building block for hydrogen-bonding receptors.