Title of article :
A novel synthesis of functionalized ketones via a nickel-catalyzed coupling reaction of zinc reagents with thiolesters
Author/Authors :
Shimizu، نويسنده , , Toshiaki and Seki، نويسنده , , Masahiko، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
Treatment of thiolesters with zinc reagents in the presence of Ni(acac)2 provided a variety of functionalized ketones in good yields. This new protocol was successfully applied to the synthesis of (+)-biotin to allow for a practical installation of the carboxybutyl chain.
Keywords :
nickel and compounds , zinc and compounds , ketones , thiolesters , coupling reactions
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
