Author/Authors :
Lange، نويسنده , , Jos H.M and Hofmeyer، نويسنده , , Lovina J.F and Hout، نويسنده , , Floris A.S and Osnabrug، نويسنده , , Stefan J.M and Verveer، نويسنده , , Peter C and Kruse، نويسنده , , Chris G and Feenstra، نويسنده , , Rolf W، نويسنده ,
Abstract :
An unprecedented microwave-enhanced Goldberg reaction constitutes the key strategic step in the synthesis of N-arylpiperazinones, N-arylpiperazinediones and N-aryl-3,4-dihydroquinolinones. Microwave irradiation greatly accelerates the Goldberg reaction using NMP as solvent. Alkylation at the 3-position of the formed N-aryl-2-piperazinones furnishes new N-aryl-3-alkyl-2-piperazinones.
