Effect of high pressure on sterically congested Passerini reactions

The effect of high pressure is examined in 3-CC (Passerini) reactions. This effect is small when moderately hindered reactants are involved. However, particularly in the case of bulky isocyanides, the sensitivity of the reaction to pressure increases with increasing steric congestion in line with earlier studies described in the reference list. Such a result highlights the synthetic utility of high pressure activation for the preparation of hindered Passerini products.