Author/Authors :
Drنger، نويسنده , , Gerald and Solodenko، نويسنده , , Wladimir and Messinger، نويسنده , , Josef and Schِn، نويسنده , , Uwe and Kirschning، نويسنده , , Andreas، نويسنده ,
Abstract :
New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition, the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity.
