Title of article
The isolation and synthesis of two novel N-acetyl glucosamine derivatives from Dictyostelium cellular slime molds which exhibit neurite outgrowth activity
Author/Authors
Kikuchi، نويسنده , , Haruhisa and Komiya، نويسنده , , Jun and Saito، نويسنده , , Yoshinori and Sekiya، نويسنده , , Jun-ichi and Honma، نويسنده , , Shigeyoshi and Nakahata، نويسنده , , Norimichi and Oshima، نويسنده , , Yoshiteru، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
1477
To page
1480
Abstract
To clarify the diversity of secondary metabolites of Dictyostelium cellular slime molds and explore any biologically active substances which they may hold, constituents of two species were investigated. From a methanol extract of their fruit bodies, two novel acylated amino sugars were isolated, dictyoglucosamine A (1) from D. purpureum and dictyoglucosamine B (2) from D. discoideum. For further analysis, these compounds were then synthesized from N-acetyl-d-glucosamine. Biological evaluation of 1 and 2 showed they induce neuronal differentiation of rat pheochromocytoma (PC-12) cells.
Keywords
cellular slime molds , Amino sugars , Differentiation , PC-12 cell
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1650082
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