Title of article :
An efficient stereoselective synthesis of Z-(2S)- and Z-(2R)-2-tert-butoxycarbonylamino-6-hydroxyhex-4-enoic acid, key intermediates in the synthesis of (2S,4S,5R)-(−)- and (2R,4R,5S)-(+)-bulgecinine
Author/Authors :
Holt، نويسنده , , Karen E. and Swift، نويسنده , , Jonathan P. and Smith، نويسنده , , Mark E.B. and Taylor، نويسنده , , Stephen J.C. and McCague، نويسنده , , Raymond، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
A concise, scaleable route to both isomers of Z-2-tert-butoxycarbonylamino-6-hydroxyhex-4-enoic acid from 2-butyne-1,4-diol, utilizing l- and d-acylase enzymes is presented. These intermediates were readily converted to multigram quantities of N-Boc-(2S,4S,5R)- and N-Boc-(2R,4R,5S)-bulgecinine.
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
