Title of article
An efficient stereoselective synthesis of Z-(2S)- and Z-(2R)-2-tert-butoxycarbonylamino-6-hydroxyhex-4-enoic acid, key intermediates in the synthesis of (2S,4S,5R)-(−)- and (2R,4R,5S)-(+)-bulgecinine
Author/Authors
Holt، نويسنده , , Karen E. and Swift، نويسنده , , Jonathan P. and Smith، نويسنده , , Mark E.B. and Taylor، نويسنده , , Stephen J.C. and McCague، نويسنده , , Raymond، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
1545
To page
1548
Abstract
A concise, scaleable route to both isomers of Z-2-tert-butoxycarbonylamino-6-hydroxyhex-4-enoic acid from 2-butyne-1,4-diol, utilizing l- and d-acylase enzymes is presented. These intermediates were readily converted to multigram quantities of N-Boc-(2S,4S,5R)- and N-Boc-(2R,4R,5S)-bulgecinine.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1650126
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