Title of article
Highly diastereoselective mercury-mediated synthesis of functionalized 2-azabicyclo[3.3.0]octane derivatives
Author/Authors
Peçanha، نويسنده , , Emerson P and Verli، نويسنده , , Hugo and Rodrigues، نويسنده , , Carlos R and Barreiro، نويسنده , , Eliezer J and Fraga، نويسنده , , Carlos A.M، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
5
From page
1607
To page
1611
Abstract
In this paper we described the synthesis of the cis-2-azabicyclo[3.3.0]octane derivative (5b) employing highly diastereoselective mercury(II)-mediated intramolecular amino-cyclization, followed by reductive demercuration of ethyl erythro-1-allyl-2-amino-1-cyclopentanecarboxylate (7b). Molecular dynamic studies were performed in order to find a suitable explanation of the diastereoselectivity of azamercuration in comparison with corresponding oxymercuration process.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1650181
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