Author/Authors :
Peçanha، نويسنده , , Emerson P and Verli، نويسنده , , Hugo and Rodrigues، نويسنده , , Carlos R and Barreiro، نويسنده , , Eliezer J and Fraga، نويسنده , , Carlos A.M، نويسنده ,
Abstract :
In this paper we described the synthesis of the cis-2-azabicyclo[3.3.0]octane derivative (5b) employing highly diastereoselective mercury(II)-mediated intramolecular amino-cyclization, followed by reductive demercuration of ethyl erythro-1-allyl-2-amino-1-cyclopentanecarboxylate (7b). Molecular dynamic studies were performed in order to find a suitable explanation of the diastereoselectivity of azamercuration in comparison with corresponding oxymercuration process.
