Title of article
Discovery, structure and HIV-1 integrase inhibitory activities of integracins, novel dimeric alkyl aromatics from Cytonaema sp.
Author/Authors
Singh، نويسنده , , Sheo B. and Zink، نويسنده , , Deborah L. and Bills، نويسنده , , Gerald F. and Pelaez، نويسنده , , Fernando and Teran، نويسنده , , Ana M. Collado، نويسنده , , Javier and Silverman، نويسنده , , Keith C. and Lingham، نويسنده , , Russell B. and Felock، نويسنده , , Peter and Hazuda، نويسنده , , Daria J. Hazuda، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
1617
To page
1620
Abstract
Integrase is a critical viral enzyme for HIV-1 replication and is a novel target for therapeutic intervention against HIV infections. Integracins A–C are three novel dimeric alkyl aromatic inhibitors of HIV-1 integrase discovered from the screening of fungal extracts using an in vitro assay. These compounds inhibit both coupled and strand transfer activity of HIV-1 integrase with IC50 values of 3.2–6.1 and 17–88 μM, respectively. The discovery, structure and activity of these compounds are described.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1650188
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