Liquid-phase combinatorial reaction monitoring by conventional 1H NMR spectroscopy

The application of 1H NMR spectroscopy for complete analysis of soluble polymer-supported reactions is described. This conventional analytical technique enables us to determine the extent of liquid-phase reactions without cleavage of the soluble matrix. The polymer matrix permitted us to obtain 1H NMR spectra with a resolution comparable with that of spectra of the molecule in solution.