Author/Authors :
Li، نويسنده , , Wen-Sen and Guo، نويسنده , , Zhenrong and Thornton، نويسنده , , John and Katipally، نويسنده , , Kishta and Polniaszek، نويسنده , , Richard and Thottathil، نويسنده , , John and Vu، نويسنده , , Truc and Wong، نويسنده , , Michael، نويسنده ,
Abstract :
Reduction of 2,6-diacetoxy-2′-bromoacetophenone (10) with NaBH4 led to 3,4-diacetoxydihydrobenzofuran (12) in a process involving acyl migration followed by cyclization. Subsequent hydrogenolysis gave 4-acetoxydihydrobenzofuran which, upon saponification, afforded 4-hydroxydihydrobenzofuran (8) in good yield. This approach is shown to be a general method for preparation of substituted dihydrobenzofurans.
