Author/Authors :
Lawson، نويسنده , , Edward C and Kinney، نويسنده , , William A and Luci، نويسنده , , Diane K and Yabut، نويسنده , , Stephen C and Wisnoski، نويسنده , , David and Maryanoff، نويسنده , , Bruce E، نويسنده ,
Abstract :
The applicability of Heck methodology to the introduction of unprotected amidines and guanidines was investigated. Unprotected guanidine-substituted olefins were coupled to various simple aryl iodides, and this methodology was then applied to a highly functionalized 6-iodoquinazolinone substrate, providing an efficient synthesis of a new class of vitronectin receptor (αVβ3 integrin) antagonists.
