Title of article
The Heck reaction with unprotected allylic amidines and guanidines
Author/Authors
Lawson، نويسنده , , Edward C and Kinney، نويسنده , , William A and Luci، نويسنده , , Diane K and Yabut، نويسنده , , Stephen C and Wisnoski، نويسنده , , David and Maryanoff، نويسنده , , Bruce E، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
3
From page
1951
To page
1953
Abstract
The applicability of Heck methodology to the introduction of unprotected amidines and guanidines was investigated. Unprotected guanidine-substituted olefins were coupled to various simple aryl iodides, and this methodology was then applied to a highly functionalized 6-iodoquinazolinone substrate, providing an efficient synthesis of a new class of vitronectin receptor (αVβ3 integrin) antagonists.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1650454
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