Synthetic studies towards paraherquamide F: synthesis of the 1,7-dihydropyrano[2,3-g]indole ring system

A substituted 1,7-dihydropyrano[2,3-g]indole suitable for elaboration to paraherquamide F has been prepared in eight steps and 6% overall yield. The key steps are a Fischer indolization and a Claisen rearrangement.