Title of article
Studies toward the total synthesis of RP-66453
Author/Authors
Boisnard، نويسنده , , Sabine and Zhu، نويسنده , , Jieping، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
2577
To page
2580
Abstract
Synthesis of a bicyclic A-B-O-C ring system of RP-66453, an neurotensine receptor antagonist, with an endo aryl–aryl and an endo aryl–aryl ether bond is described. An alternative synthetic strategy starting from the construction of functionalized B-O-C cycloisodityrosine unit is also detailed.
Keywords
neurotensine receptor antagonist , RP 66453 , Biaryl , macrocycle , biaryl ether , intramolecular SNAr reaction
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1650880
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