Title of article
Dynamic kinetic resolution of γ-hydroxy acid derivatives
Author/Authors
Runmo، نويسنده , , Ann-Britt L and Pàmies، نويسنده , , Oscar and Faber، نويسنده , , Kurt and Bنckvall، نويسنده , , Jan-E، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
4
From page
2983
To page
2986
Abstract
Enzymatic resolution and dynamic kinetic resolution of γ-hydroxy acid derivatives 1 have been investigated. Efficient kinetic resolution was obtained using Pseudomonas cepacia lipase in toluene (E value ∼400). The combination of enzymatic kinetic resolution with a ruthenium-catalyzed racemization resulted in an efficient dynamic kinetic resolution. The use of a hydrogen source to depress ketone formation in the dynamic kinetic resolution yields the corresponding acetates in good yield (up to 93%) and enantioselectivity (up to 99%).
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1651189
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