Author/Authors :
Bijani، نويسنده , , Christian and Varray، نويسنده , , Stéphane and Lazaro، نويسنده , , René and Martinez، نويسنده , , Jean and Lamaty، نويسنده , , Frédéric and Kieffer، نويسنده , , Nelly، نويسنده ,
Abstract :
A cyclic pseudopeptide containing the RGD sequence has been synthesized in high yield by ring-closing metathesis using a Grubbs’ catalyst in tetrahydrofuran. Conformational analysis has been correlated to structure modeling and preliminary biological activity as an integrin binding inhibitor has been evaluated.
