Author/Authors :
Liang، نويسنده , , Jiangong and He، نويسنده , , Zhike and Zhang، نويسنده , , Shusheng and Huang، نويسنده , , Shan and Ai، نويسنده , , Xinping and Yang، نويسنده , , Hanxi and Han، نويسنده , , Heyou Han، نويسنده ,
Abstract :
The calf thymus DNA (ctDNA) damage induced by water-soluble CdSe quantum dots (QDs) was investigated using nucleic acid molecular “light switches” as probe. It was found that little ctDNA was damaged by CdSe QDs without UV irradiation. However, under UV irradiation, ctDNA was nicked by CdSe QDs very clearly. The mechanism of ctDNA damage was also discussed. The results strongly suggested that the ctDNA damage caused by CdSe QDs was not due to photo-induced liberation of Cd2+, but due to the production of free radicals and reactive oxygen species.
Keywords :
Damage , Quantum dots , DNA , Nucleic acid molecular “light switches”
