Title of article :
Convenient synthesis of Cbz-protected β-amino ketones by a copper-catalysed conjugate addition reaction
Author/Authors :
Wabnitz، نويسنده , , Tobias C and Spencer، نويسنده , , Jonathan B، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
A convenient synthesis of Cbz-protected β-amino ketones is reported. Benzyl carbamates and α,β-unsaturated ketones furnish the conjugate addition products in the presence of a Cu(II) catalyst under mild conditions. Other weakly basic nitrogen nucleophiles can also be used in this reaction.
Keywords :
benzyl carbamate , conjugate addition , Copper , ?-amino ketones , nitrogen nucleophiles
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
