Title of article
Pseudo-prolines (ΨPro): direct insertion of ΨPro systems into cysteine containing peptides
Author/Authors
Guichou، نويسنده , , Jean-François and Patiny، نويسنده , , Luc and Mutter، نويسنده , , Manfred، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
2
From page
4389
To page
4390
Abstract
The direct conversion of cysteine (Cys) containing peptides into conformationally constrained pseudo-proline (ΨPro) derivatives by intraresidual N,S-acetalisation has been achieved. This post-synthetic modification represents a versatile tool in structure–activity studies of bioactive peptides as exemplified for the immunosuppressive cyclosporine A (CsA) analogue [D-Cys]8CsA.
Journal title
Tetrahedron Letters
Serial Year
2002
Journal title
Tetrahedron Letters
Record number
1652188
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