Author/Authors :
Cheng، نويسنده , , Jie-Fei and Kaiho، نويسنده , , Christopher and Chen، نويسنده , , Mi and Arrhenius، نويسنده , , Thomas and Nadzan، نويسنده , , Alex، نويسنده ,
Abstract :
A traceless solid-phase synthesis of 2-imidazolones has been developed. Polymer-bound glycerol resin was reacted with bromoacetaldehyde diethyl acetal to give the cyclic acetal bromide on the solid support. Amination of the resin-bound acetal bromide followed by urea formation by reaction with isocyanates afforded the resin-bound urea acetals. The aldehyde urea intermediate, which was released from the resin upon treatment with TFA, immediately cyclized to afford the desired 2-imidazolones in good yield and purity.
