Electrolytic partial fluorination of organic compounds. Part 61: The first example of direct α-fluorination of protected α-amino acids

Regioselective anodic α-monofluorination of oxazolidines 1 derived from α-amino acid was successfully carried out. This is the first example of the successful, direct α-fluorination of protected amino acids. Anodic fluorination of methyl N-acetyl pyroglutamate also provided the corresponding α-fluorinated product in moderate yield, while the anodic fluorination of an open-chain α-amino acid, N-(carboethoxy)methylphathalimide, was unsuccessful.