Asymmetric synthesis of (+)-indatraline using rhodium-catalyzed C–H activation

The potent monoamine reuptake inhibitor (+)-indatraline, 1, was prepared in greater than 98% ee employing a highly enantioselective carbenoid C–H insertion reaction into 1,4-cyclohexadiene catalyzed by the chiral rhodium complex, Rh2(S-DOSP)4.