Author/Authors :
Li، نويسنده , , Sheng-Hong and Zhang، نويسنده , , Hong-Jie and Qiu، نويسنده , , Sheng-Xiang and Niu، نويسنده , , Xue-Mei and Santarsiero، نويسنده , , Bernard D. and Mesecar، نويسنده , , Andrew D. and Fong، نويسنده , , Harry H.S. and Farnsworth، نويسنده , , Norman R. and Sun، نويسنده , , Han-Dong، نويسنده ,
Abstract :
A novel labdane diterpene alkaloid, vitexlactam A (1) was isolated as a prism from the n-hexane extract of the fruits of Vitex agnus-castus through normal and reverse phase column chromatography. Its structure was elucidated to be 6β-acetoxy-9α-hydroxy-13(14)-labden-16,15-amide, based on chemical and spectral evidences including 1D and 2D NMR spectra. The structure was confirmed by X-ray crystallographic analysis. Compound 1 is the first naturally occurring labdane diterpenoid containing an α,β-unsaturated γ-lactam moiety.
Keywords :
X-Ray , Verbenaceae , vitexlactam A , NMR , Vitex agnus-castus , Lactam , Labdane diterpene
