Design, synthesis and membrane ion transport properties of cystine- and serine-based cyclo-4-oxa-heptane-1,7-bisamides

A new class of cyclobisamides, having the general profile of amino acid (cystine or serine)–ether composites, as potentially efficient ion transporters has been designed and synthesized. In model membranes, the adamantane harboring composites exhibited 57–66% of gramicidin A activity in ion transport.