Biomimetic reductive amination of perfluoroalkylcarboxylic acids to α,α-dihydroperfluoroalkylamines

The first general method for the reducing reagent-free, biomimetic transformation of perfluorocarboxylic acids to the α,α-dihydroperfluoroalkyl amines is reported. High chemical yields and simplicity of the experimental procedure render this method immediately useful and synthetically superior to the conventional approaches relying on application of reducing reagents.